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Tomato is an imperative fruit/vegetable crop and a treasure trove of active natural metabolites. It is cultivated across the globe but both biotic and abiotic factors have been implicated in decreasing its production. Among all the constraints faced by tomato crop in Pakistan, bacterial canker of tomato caused by Clavibacter michiganensis subsp. michiganensis (Cmm is one of the most ravaging biotic stss to tomato crop. Present study was designed to evaluate antibacterial potential of different chemicals (Cabrio Top, Oxyrich, Kocide, Electus super, and Forum top) against Clavibacter michiganensis subsp. michiganensis under vitro and vivo conditions at three different concentrations. In vitro condition, efficacy of these chemicals was determined at (250ppm, 500ppm,750pp) concentrations out of which Electus super showed maximum inhibition zone at 750ppm concentration. In field condition, kocide and electus super were applied separately and in combination and in combination significant result was expressed with minimum disease incidence. The current investigations pave the way for fruitful disease management through certain chemicals because of their easy availability, fast action and cost effectiveness.